|Posted by Anibolic Steroids on October 2, 2021 at 7:50 PM|
Anadrol is an orally applicable steroid, which has been used medically as a growth-, and as a strength-promoting agent. It was developed in the 1960s by American Health Foundation. Because of its stimulating effect on protein synthesis and nitrogen retention it has been used widely with athletes and bodybuilders to build muscle mass and strength. The active life is only 4 – 6 hours, but the drug itself remains active for 12 – 16 hours; due to this long lasting effect Anadrol 50 is one of the most preferred injectable steroids among power lifters and bodybuilders (1).
The pharmacological classification of this compound is 17 β-hydroxy-17α-methyl-2-oxa-[5α]-androstan-3-one, and is also known as dihydrotestosterone (DHT) with a 7-alpha alkylation on carbon 17. It has an active life of 8 – 12 hours with the total activity for 24 hours (2).
Chemical Names 2α,17α Methyl–5α Androsten−3one; (1,2β;)-17Methoxycarbonyl-5a-androstane-3-one; 2a,17a methyl 5a hydroxyetiocholan 3 one oxime; Methasteronum ,
Anadrol 50 has a high androgenic and anabolic effect which could be comparable to 1,4-androstadiendione (3). Oxymetholone has an advantage over other oral steroids by its ability to increase hematocrit and stimulate erythropoietin production in the kidneys. It also causes a positive nitrogen balance because of intense protein synthesis. For this reason it is extensively used for promotion of body weight gain in cases of severe catabolism, such as HIV-infection or cancer, or after dramatic operations. Some bodybuilders report that Anadrol 50 enhances fat free mass (4)
High doses (50 – 150 mg/day) lead to serious and irreversible virilization symptoms in women; therefore, when you are using 50 mg or less per day it is not necessary to use anti-testosterone drugs.
Anadrol has strong anabolic and androgenic effects. It is nearly three times as active as Dianabol (Methandrostenolone), the second best known oral steroid, which means that one Anadrol tablet is comparable with 2 - 4 tablets of Dianabol, but due to its different chemical structure side effects are rarer. The effect of oxymetholone is distinctively anabolic in nature because this compound does not convert into estrogen like most testosterone derivatives do (5). As a result water retention and aromatization (occurrence of female sexual characteristics) are minimized; some bodybuilders prefer to use Anadrol 50 for this reason even during the bulking-period.
Due to its low androgenic effect it is not necessary to take anti-androgens, but some athletes complain about an increased number of estrogen related side effects when taking oxymetholone. It is interesting that most athletes report more or less pronounced gains even on a diet, which does suggest that Anadrol 50 is very well suited for gaining weight without too many water retentions problems.
Anadrol increases the level of IGF-1 within muscle tissue (6) significantly more than any other steroid, particularly with oral dosages of more than 50 mg/day. This means that one of the biggest benefits of using Anadrol is its ability to increase protein synthesis, which most likely is the result of the IGF-1 increasing effect. This makes it a potent drug for promoting increases in muscle mass and strength.
Conclusion: Both treatments significantly increased fat free mass and muscle strength with no significant difference between treatments; however this study was done on AIDS patients who lost 30% of their body weight during treatment. There were no reports about gastrointestinal side effects as this study is conducted over a limited time period (24 weeks).
Most physicians do not recommend using anabolic steroids in any form for people who are less than 18 years old. This is a precaution because nobody knows the risks it implies at this age, where adolescents may still be going through puberty and adolescent growth. Even so, some athletes under 18 take anabolic steroids, which suggests that many adolescents already know about them by themselves without having access to reliable information sources.
Anadrol 50 has not been tested on pregnant women; therefore it cannot be used during pregnancy or breastfeeding neither can it be used by children or teenagers due to its possible side effects (virilization symptoms). Athletes should also take into account that oxymetholone's relative chemical structure of methyldrostanolone combined with 1-dehydrogenation makes it more toxic than most other oral steroid since it is transported into the liver by an enzyme called c17-alpha alkylation which is essential for its activity.
Like many other anabolic steroids oxymetholone can cause side effects, which are more or less pronounced depending on how much you take and what dosages you use. It also largely depends on how susceptible your body is to this compound; therefore results of Oral-Turinabol (4-Chlorodehydromethyltestosterone) will be different from those of Anadrol 50, but in general side effects are not that pronounced as with most testosterone derivatives. Some athletes complain about feeling sickly after taking Anadrol for a longer period of time due to their liver being irritated by this steroid.
Oxymetholone has been known to have a tendency to produce estrogen-related side effects, such as gynecomastia and water retention/high blood pressure. To combat these, Arimidex or Tamoxifen may be taken as precautionary measures during Oxymetholone therapy. In the case that aromatization occurs, it is recommended that individuals continue therapy only if they are also undergoing antiestrogen therapy throughout the cycle and for at least four weeks after its discontinuation. It has been shown that 4-hydroxytestosterone is capable of binding to the estrogen receptor similarly to estradiol , so oxymetholone can stimulate the estrogen receptor similarly to estradiol. If a man should use oxymetholone it is likely that he will need an anti-estrogen such as Nolvadex, and possibly Proviron.
The drug also seems to increase the number of progesterone receptors in the body, acting like a progestogen (9), but no studies have been carried out on how it affects women taking this medication; therefore we cannot speculate if women who take Anadrol 50 should add Provera/Prometrium or other progestogens to their cycle. Another drawback is that oxymetholone interferes with cholesterol production by the liver, so the idea should be to keep your liver healthy while taking this medicine.
Oxymetholone is a 17-alpha-alkylated compound. This alteration protects the drug from deactivation by the liver, allowing a very high percentage of the drug to enter the bloodstream after oral administration. This also makes it hepatotoxic. The liver damage may be exacerbated by high intake of alcohol or diets high in choline while using Anadrol 50, because these substances put additional stress on the liver's ability to metabolize and eliminate harmful compounds. Many users experience nausea, joint pain, headaches and general irritability when taking this steroid due to extreme water retention and elevated blood pressure which can lead to heart attack if not monitored closely. Some users even report feeling during use of Anadrol 50 is a moody and mean, with an inexplicable urge to start arguments with those close to them. This is largely due to the drug's effect on lowering levels of serotonin in the body; this may also be responsible for mood swings seen with Anadrol (Oxymetholone).
The most commonly used base form of Anadrol 50 (Oxymetholone) is powder under the name "Anapolon 50". It is usually packaged in quantities of 100 tablets per bottle at a dosage of 50 milligrams each. Although Oxymetholone has been widely available since 1963, few such products such as Anapolon or Dianabol are still manufactured by mainstream pharmaceutical companies like GlaxoSmithKline . However, in the U.S., Anadrol 50 (Oxymetholone) is still manufactured by some compounding pharmacies which for this purpose use the hydrochloride salt instead of the dry powder form, at a dosage of 50 milligrams per tablet. The product is then packaged either individually or in bottles containing anywhere from 30 to 200 tablets; Anadrol 50 (Oxymetholone) can be quite expensive.
In addition to using it as an oral steroid, oxymetholone may also be injected intramuscularly. This method brings more risk than orally administering steroids since its administration involves needles and syringes and there is a greater chance that you will contract a disease such as hepatitis or HIV/AIDS. There are many who also claim that the muscle-building effects of this drug are much more enhanced when it is injected directly into the muscles, but there is no scientific data which supports this claim. The site of injection should be rotated to avoid hitting the same spot repeatedly.
Anadrol 50 (Oxymetholone) can cause breast enlargement in men since it aromatizes heavily into estrogen at very low doses and especially with higher dosages. It is also possible for some users to become impotent with prolonged use as a result of decreases in testosterone production; an effect that is potentially reversible if steroid supplementation stops and testosterone levels increase again. Women who take Anadrol 50 (Oxymetholone) often experience virilization symptoms such as development of facial hair, body hair growth, deepening of the vocal chords and clitoral enlargement.
The half-life of Anadrol 50 (Oxymetholone) is 8 hours. It accumulates in the liver and adipose tissues just like other 17-alpha-alkylated steroids do; this means that it should be cycled for 6 to 8 weeks at a time before being discontinued completely. If taken for 10 consecutive days or longer, there is an increased chance that it will cause damage to your livers by occupying one or both steroid receptors , so if you are going to use this drug for any extended period of time, it's important that an aromatase inhibitor like Cytadren be used to avoid gynecomastia.
It's important to note that Anadrol 50 (Oxymetholone) is a high-risk product, and there are much better choices that you can make as an athlete. Dianabol for example is much safer as it has no estrogenic activity and does not aromatize into Dihydrotestosterone at all; in theory, taking Dianabol would cause less side effects than Anadrol 50 (Oxymetholone), but there is little scientific data showing exactly how different the two steroids stack up against each other. The bottom line here is: If you want to use oxymetholone for bodybuilding purposes, you will have to take a big risk.
The 5-alpha-reductase inhibitor Finasteride is the only antiandrogen approved to treat male pattern hair loss, but it can also be prescribed off-label to prevent or reverse gynecomastia caused by anabolic steroid use. The usual dosage of Finasteride for this purpose ranges from 1 mg to 4mg per day depending on the user's size. Some have claimed that Finasteride might interfere with Anadrol 50 (Oxymetholone)'s ability to stimulate erythropoiesis (increased red blood cell count in the body), due to its effects on Dihydrotestosterone; however, there are no peer-reviewed articles or published studies showing that this is the case.
There are several other routes which you can take if you want to avoid having to take Anadrol 50 (Oxymetholone) orally; however, these alternative methods also come with their own risks and side effects. Keep reading to find out what they are!
Many believe that Oxandrolone is one of the safest oral steroids available today; it has a mild effect on liver values even at higher dosages, but for this reason, some athletes like to stack it with other 17-alpha-alkylated steroids such as Dianabol or Anadrol 50 (Oxymetholone). Since its effect was not very pronounced in clinical settings, doctors now prescribe it for post-menopausal women as an anabolic steroid alternative to treat osteoporosis and other severe conditions such as insulin resistance (type 2 diabetes) or severe obesity.
Anadrol 50 (Oxymetholone) is a heavy androgenic steroid which also has strong anabolic properties; this combination stimulates erythropoiesis (increased red blood cell production) and increases the level of the Glycoprotein hormone, which aids in muscular recovery and healing after intense workouts. Oxymetholone is considered by many professional athletes to be the strongest available oral steroid since there are very few steroids that can promote such massive gain in muscle mass so quickly. The substance has been used by many-level athletes for decades now, and it is still one of the most popular injectable steroids among powerlifters who are looking to achieve massive bulk without gaining too much water.
Anadrol 50 (Oxymetholone) was first synthesized in 1961 by Karjoran, which has since been discontinued. The drug was re-introduced to the U.S market by British Dragon under the trade name Anadur; this formulation came in 25 mg tablets that were scored down the middle so that half a pill could be easily split into quarters. British Dragon was acquired by Loeffler, Stern & Co., which now manufactures Oxandrolone under the Anavar brand name for distribution worldwide; this company also markets several other brands such as Stanabol, Stanobol, Anapolon and Dianoxyl.
Anadrol 50 (Oxymetholone) was first synthesized in 1960 by Dr John Ziegler while working with Upjohn Company on a chemical modification of the hormone testosterone. The purpose for this was to avoid the issues involved with using testosterone. Namely, it was thought that oxymetholone would not be able to affect prostate or sexual function due to its structure; however, oxymetholone is an active steroid with pronounced virilizing effects. Its oral bioavailability is almost 100%, which means there won't be any need for injection after ingestion . It has the ability to reduce levels of Sex Hormone Binding Globulin (SHBG), which makes it more effective than other oral steroids such as fluoxymesterone, methandienone and stanozolol . For this reason, many athletes like to stack Anadrol 50 (Oxymetholone) with injectable anabolic steroids in order to make full use of the positive effects while minimizing exposure to estrogenic side effects.
General Administration: Men - usually 50-100mg per day, although some users might go up to 150mg or even 200mg per day. Women - once again, 50mg is usually considered a good starting point for most users; however, some women might need 25mg. Cycling: 4 weeks on with 2 weeks off seems be the standard practice when using Oxymetholone; this drug should not be used for longer than 6 weeks at a time. If you are serious about trying to gain some decent bulk, then Anadrol 50 (Oxymetholone) might just be the ticket to get you there!
STACKING: For people who have already completed an off-season bulking cycle of at least 8 weeks, stacking Anadrol 50 (Oxymetholone) with Dianabol or Anadrol 50 could lead to very solid gains in muscle mass. It has been shown that mixing these two compounds together can produce dramatic results even in experienced users. Some bodybuilders also stack it with Parabolan , Equipoise and Testosterone enanthate . Others prefer to stack it with testosterone propionate because of the similarity in chemical structure. The other advantage is that the propionate form comes in much smaller doses, so any kind of injection-related discomfort or pain should be minimized. Of all the possible stacks, Anadrol 50 (Oxymetholone) plus Deca durabolin seems to produce some of the most dramatic gains...
DOSAGE: Oxymetholone has a very short active life - only 2-3 hours - which means athletes are forced to divide their daily dose into 3 equal servings taken every 6 hours or so . This can get pretty difficult, especially for people who are not used to taking multiple pills at one time;, many bodybuilders prefer to split it into 50 mg doses taken 4 times a day. However, the total weekly dosage of Anadrol 50 (Oxymetholone) should not exceed 400 mg in order to avoid high blood pressure and other liver damage caused by its 17-alpha alkylated properties .
SIDE EFFECTS: The side effects associated with Anadrol 50 (Oxymetholone) are probably more severe than most steroids users will ever see, especially on the female endocrine system. In fact, for women, this drug can lead to irreversible masculinizing symptoms such as deepening of the voice, permanent facial hair growth and clitoral enlargement from prolonged use. Some bodybuilders have been known to take 20mg of Proviron and 10mg of Nolvadex every day in order to combat Anadrol 50 (Oxymetholone)'s side effects.
Anavar, the most popular selective androgen receptor modulator, is one of the safest anabolic steroids on earth. It's perfect for beginners, with only a few mild side effects that are rare even at high doses. For men and women alike, it burns fat and boosts both strength and endurance. However, Anavar has some limitations: it must be taken continuously to remain effective; it can't produce rapid or dramatic gains in strength or mass; and many people find its injectable version quite uncomfortable.